Scientists find a strain of super-mice that just can't get cancer.

[MeDieViL]

Vond dit wel intressant
Are You Immune to Cancer?
Scientists find a strain of super-mice that just can't get cancer.
By Jessica Ruvinsky
DISCOVER Vol. 27 No. 08 | August 2006 | Medicine


Seven years ago, biochemist Zheng Cui of Wake Forest University was conducting a routine experiment, injecting test mice with a strain of cancer cells so aggressive it caused a 100 percent death rate. Oddly, one of the mice wouldn't die. Thinking he had made an error, Cui injected the mouse with a million times the lethal dose, but it still lived.

Cui was intrigued. He bred the mouse and found that 40 percent of its offspring share a remarkable resistance to many forms of cancer. When the animals' immune systems identify a cancer cell, a genetic tweak allows their bodies to launch a massive attack of white blood cells that kills the budding tumor.

Now Cui and his colleagues have found a clue that may point the way to an actual cure. When they inject white blood cells from any of these anticancer mice into their nonresistant brethren, the injected animals become resistant as well, fighting off induced cancer in a matter of weeks or avoiding it entirely.

Even more promising, Cui has sampled a group of human volunteers and found that 10 to 15 percent have similar super cancer-fighting white blood cells. That could explain why some people never get cancer and why others' tumors spontaneously regress. Cui proposes injecting these people's white blood cells into cancer patients to see if he can transfer their immunity.

Other, more established oncologists point out that Cui's mice are genetically uniform; humans, with their distinct DNA differences, would run a deadly risk of the donated cells attacking their host, even if they aren't rejected first. Cui counters that these issues could be overcome, as they have been for other types of transplants. "All the delivery mechanisms are in place," he says. "We truly believe that this is a viable approach."

Are You Immune to Cancer? - - science news articles online technology magazine articles Are You Immune to Cancer?

[ijzer]

Origineel gepost door MeDieViL

injecting test mice with a strain of cancer cells so aggressive it caused a 100 percent death rate. Oddly, one of the mice wouldn't die. Thinking he had made an error, Cui injected the mouse with a million times the lethal dose, but it still lived.

Thats what I call Hardcore to the bone

[MeDieViL]

Origineel gepost door ijzer

Thats what I call Hardcore to the bone

hardcore muizen

[Ari70]

Vaag.. vaag.. hopelijk hebben ze voorde rest nog iets aan het onderzoek gehad! en kunnen ze het bij een mens implementeren en dan moeten ze weer klonen (en dat mag dan weer niet.. ) kunnen ze die regels niet omzeilen?

[MeDieViL]

Origineel gepost door Ari70

Vaag.. vaag.. hopelijk hebben ze voorde rest nog iets aan het onderzoek gehad! en kunnen ze het bij een mens implementeren en dan moeten ze weer klonen (en dat mag dan weer niet.. ) kunnen ze die regels niet omzeilen?

klonen? medicatie met hetzelfde effect zou toch een beter begin zijn

[Big T]

Niet echt iets te maken met BB, maar wel een interessante vondst in de wetenschap rond kanker.

[3XL]

Het wachten is op anti-oxidanten die berusten op deze witte bloedcellen

[Little Me]

Zou wel super zijn mocht er eens een sterke doorbraak zijn op het gebied van kanker .

[Tays]

Dit soort artikelen vind ik erg intressant vraag me vaak af waarom aan dit soort dingen niet meer media aandacht besteed wordt

[davy1010]

Inderdaad, dergelijk "goed" nieuws is blijkbaar niet populair genoeg, liever nog wat meer oorlog en aanslagen in het nieuws.

[Big'r]

Origineel gepost door MeDieViL

Even more promising, Cui has sampled a group of human volunteers and found that 10 to 15 percent have similar super cancer-fighting white blood cells. That could explain why some people never get cancer and why others' tumors spontaneously regress. Cui proposes injecting these people's white blood cells into cancer patients to see if he can transfer their immunity.

Other, more established oncologists point out that Cui's mice are genetically uniform; humans, with their distinct DNA differences, would run a deadly risk of the donated cells attacking their host, even if they aren't rejected first. Cui counters that these issues could be overcome, as they have been for other types of transplants. "All the delivery mechanisms are in place," he says. "We truly believe that this is a viable approach."

Are You Immune to Cancer? - - science news articles online technology magazine articles Are You Immune to Cancer?

Interessante shit! Interessant voorstel ook van Cui. Helaas staat deze vorm van onderzoek nog in de kinderschoenen. Snap zelf totaal niet waarom ze dit soort dingen niet eerder hebben overwogen!!!

Kwam alleen een studie tegen waarin ze menselijk DNA met enig succes in honden injecteerden:


Vaccination with human tyrosinase DNA induces antibody responses in dogs with advanced melanoma.
Antitumor immune responses can be elicited in preclinical mouse melanoma models using plasmid DNA vaccines encoding xenogeneic melanosomal differentiation antigens. We previously reported on a phase I clinical trial of human tyrosinase (huTyr) DNA vaccination of 9 dogs with advanced malignant melanoma (World Health Organization stages II-IV), in which we demonstrated the safety of the treatment and the prolongation of the expected survival time (ST) of subjects as compared to historical, stage-matched controls. As a secondary goal of the same study, we report here on the induction of tyrosinase-specific antibody responses in three of the nine dogs vaccinated with huTyr DNA. The antibodies in two of the three responders cross-react with syngeneic canine tyrosinase, demonstrating the ability of this vaccine to overcome host immune tolerance and/or ignorance to or of "self" antigens. Most interestingly, the onset of antibody induction in these three dogs coincides with observed clinical responses and may suggest a means to account for their long-term tumor control and survival.

[MeDieViL]

wedden dat de stichting tegen kanker ofzo hier geen weet van heeft, en wss hoor je ook in de toekomst hier niet veel meer van

ze zouden over de wereld moeten samenwerken, om zo snel mogelijk een medicijn tegen kanker te vinden!

[SHUTTERSPEED]

goed artikel en ja samenwerking is soms ver te zoeken helaas.

[Trickolutions]

Dit artikel verdient duidelijk karma bro, bedankt! Ben erg geinteresseert hierin en dit is wel opmerkelijk!

[jody]

Mighty mouse
up up ... and awaaaaaayyyy