nicotine goed wtf?

[MeDieViL]

Nicotine helpt (wetenschappelijk onderzoek)

Toch eens een keer iets positiefs over nicotine. Deze stof blijkt in staat de ernst te verminderen van sepsis, een levensbedreigende (over)reactie van het afweersysteem op bacteriën die het lichaam zijn binnengedrongen.
Nicotine onderbreekt de op hol geslagen ketting van reacties van het afweersysteem die op gang komt bij sepsis, schrijft H. Wang (North Shore University Hospital, New York) in het vakblad Nature Medicine op grond van onderzoek bij ratten.

Andere onderzoeken hebben ook al gemeld dat nicotine goed is om het geheugen te verbeteren en dat het dementie kan verhinderen.

http://www.jankraak-taichitao.nl/con...pagina_id=1061
op het eerste zicht lijkt die site wil bullshit ja, van yin en yang gedoe, doe geen moeite om alles te lezen, valt toch niet te begrijpen

maar nu is mijn vraag, is nicotine toch niet zo'n slechte stof?

[roxxe]

It is a potent nerve poison and is included in many insecticides.

http://en.wikipedia.org/wiki/Nicotine

voor & na delen dus

[Big T]

Bijna alle drugs hebben ergens voordelen, het zijn de verslaving en neveneffecten die het ongezond en gevaarlijk maken.

[3XL]

Vind het altijd "gewaagd' als een onderzoek op muizen rechtstreeks op mensen geprojecteerd wordt

Nicotine's Good Side: Substance curbs sepsis in mice
Diana Parsell

Small doses of nicotine can halt the progression of the often-fatal condition called sepsis, according to experiments in mice. The finding, coupled with tests of nicotine on cultured human cells, suggests a pathway to more-effective therapies for the infection-triggered problem.

Twice as many mice injected with nicotine survived at least 3 weeks after sepsis set in than did mice receiving inert injections. Luis Ulloa of the Institute for Medical Research at North Shore-Long Island Jewish Health System in Manhasset, N.Y., and his coinvestigators conclude that the treatment works by inhibiting overproduction of an immune system molecule that promotes inflammation.

Other studies have suggested that nicotine may be effective against inflammatory diseases such as ulcerative colitis, which is chronic inflammation of the large intestine.

When Ulloa and his colleagues began experimenting in lab dishes with human macrophages, a type of immune system cell, they discovered that the biochemical acetylcholine put the brakes on the cells' production of the protein called high mobility group box 1 (HMBG1). This protein is one of the family of immune chemicals called cytokines, which play a role in infection-fighting inflammation. In sepsis, however, HMBG1 overstimulates inflammation.

Knowing that acetylcholine acts through immune-cell receptors that also bind nicotine, the researchers tested that chemical on the human cells. It triggered a strong anti-inflammatory effect.

The researchers then injected doses of nicotine into one of two sets of mice in which they had induced sepsis by infecting the animals with bacteria. After 24 hours, the mice receiving nicotine had lower concentrations of HMBG1 proteins in their bloodstreams than the other mice did, the team reports in the November Nature Medicine.

To find out whether this effect can improve survival, the researchers induced sepsis in mice and then injected one group of mice with nine doses of nicotine over 3 days and gave another group an inert solution. After 3 weeks, 81 percent of the mice that had received the nicotine were still alive, compared with 44 percent in the group getting inert injections.

Ulloa expects the findings to lead to the development of new, nicotinelike compounds that can reduce inflammatory diseases while avoiding the side effects of nicotine, which include nausea and heart and blood vessel problems. "However, these are preclinical studies, and future studies are needed to evaluate potential effects of human use" of such compounds, he adds.

Effective new therapies for sepsis could have tremendous medical benefits. In the United States, sepsis kills a third of the 750,000 people who experience it each year, accounting for 9 percent of U.S. deaths. Current treatment consists of antibiotics and critical care to prevent organ failure, but sepsis often spreads too rapidly for physicians to halt its damage.

Pathologist Peter A. Ward of the University of Michigan Health System in Ann Arbor says, "There's every reason to think [the new finding] might ultimately have clinical implications." The goal for treatment of sepsis and other inflammatory conditions, he explains, is to find ways of enlisting the body's natural regulators.


En even uit dit artikel http://www.medscape.com/viewarticle/493390 waar dieper ingegaan word op het nicotine/sepsis/Wang etal verhaal

Wang et al.[6] have used nicotine to activate the cholinergic anti-inflammatory pathway and report that this treatment reduced mortality in mice with polymicrobial peritonitis from 84 to 51% -- even when administered after the mice appeared clinically ill. The authors provide in vitro evidence that nicotine is associated with a reduction in activation of the proinflammatory transcriptional factor NF-κB in macrophages, an effect that is mediated by the specific nicotinic acetylcholine receptor, α7nAChR.

[MeDieViL]

kunne we allemaal aan de pleisters gaan zitte

[king ralf]

Origineel gepost door 3XL

Vind het altijd "gewaagd' als een onderzoek op muizen rechtstreeks op mensen geprojecteerd wordt

Nicotine's Good Side: Substance curbs sepsis in mice
Diana Parsell

Small doses of nicotine can halt the progression of the often-fatal condition called sepsis, according to experiments in mice. The finding, coupled with tests of nicotine on cultured human cells, suggests a pathway to more-effective therapies for the infection-triggered problem.

Twice as many mice injected with nicotine survived at least 3 weeks after sepsis set in than did mice receiving inert injections. Luis Ulloa of the Institute for Medical Research at North Shore-Long Island Jewish Health System in Manhasset, N.Y., and his coinvestigators conclude that the treatment works by inhibiting overproduction of an immune system molecule that promotes inflammation.

Other studies have suggested that nicotine may be effective against inflammatory diseases such as ulcerative colitis, which is chronic inflammation of the large intestine.

When Ulloa and his colleagues began experimenting in lab dishes with human macrophages, a type of immune system cell, they discovered that the biochemical acetylcholine put the brakes on the cells' production of the protein called high mobility group box 1 (HMBG1). This protein is one of the family of immune chemicals called cytokines, which play a role in infection-fighting inflammation. In sepsis, however, HMBG1 overstimulates inflammation.

Knowing that acetylcholine acts through immune-cell receptors that also bind nicotine, the researchers tested that chemical on the human cells. It triggered a strong anti-inflammatory effect.

The researchers then injected doses of nicotine into one of two sets of mice in which they had induced sepsis by infecting the animals with bacteria. After 24 hours, the mice receiving nicotine had lower concentrations of HMBG1 proteins in their bloodstreams than the other mice did, the team reports in the November Nature Medicine.

To find out whether this effect can improve survival, the researchers induced sepsis in mice and then injected one group of mice with nine doses of nicotine over 3 days and gave another group an inert solution. After 3 weeks, 81 percent of the mice that had received the nicotine were still alive, compared with 44 percent in the group getting inert injections.

Ulloa expects the findings to lead to the development of new, nicotinelike compounds that can reduce inflammatory diseases while avoiding the side effects of nicotine, which include nausea and heart and blood vessel problems. "However, these are preclinical studies, and future studies are needed to evaluate potential effects of human use" of such compounds, he adds.

Effective new therapies for sepsis could have tremendous medical benefits. In the United States, sepsis kills a third of the 750,000 people who experience it each year, accounting for 9 percent of U.S. deaths. Current treatment consists of antibiotics and critical care to prevent organ failure, but sepsis often spreads too rapidly for physicians to halt its damage.

Pathologist Peter A. Ward of the University of Michigan Health System in Ann Arbor says, "There's every reason to think [the new finding] might ultimately have clinical implications." The goal for treatment of sepsis and other inflammatory conditions, he explains, is to find ways of enlisting the body's natural regulators.


En even uit dit artikel http://www.medscape.com/viewarticle/493390 waar dieper ingegaan word op het nicotine/sepsis/Wang etal verhaal

Wang et al.[6] have used nicotine to activate the cholinergic anti-inflammatory pathway and report that this treatment reduced mortality in mice with polymicrobial peritonitis from 84 to 51% -- even when administered after the mice appeared clinically ill. The authors provide in vitro evidence that nicotine is associated with a reduction in activation of the proinflammatory transcriptional factor NF-κB in macrophages, an effect that is mediated by the specific nicotinic acetylcholine receptor, α7nAChR.

pffffffffffffffffffffffffffffffffffffffffffffffffffffffffffff

[s0lar]

Nicotine verbeterd de hand-oog coordinatie en is dus heel handig voor technische sporten zoals pingpong, tennis en BADMINTON. Als je een half uurtje voor een wedstrijd een kauwgom met nicotine eet dan is de nicotine naar je hersenen gedrongen. Via een sigaret duurt het 10sec maar dan heb je wel veel meer nadelen.

[builderB]

Ik heb in een T-nation artikel over de wedstrijd voorbereiding van een missfigure (die overigens behoorlijk diep gaat...) gelezen dat ze voor spotvetverbranding nicotine pleisters gebruikten.

edit: ik heb het gevonden, interessant artikel:
Testosterone Nation - Fat to Figure

[MeDieViL]

nicotine werkt zoals cafeine en zoals amfetamines (in mindere mate) door hoeveelheid dopamine te verhogen, de effecten zijn dus een beetje verglijkbaar

[Big'r]

Origineel gepost door 3XL

Vind het altijd "gewaagd' als een onderzoek op muizen rechtstreeks op mensen geprojecteerd wordt

Helemaal mee eens. En dan vind ik het nog voorzichtig uitgedrukt.
Het zegt echt compleet 0,0 en niet meer!

Er is een volgorde waarin wetenschappelijke onderzoeken als "bewijslast" worden gezien.

Randomized studies staan boven cohort studies. Die staan weer boven ecologisch onderzoek, en daarna komen case control studies in mensen.
Dierstudies komen hier niet eens in voor.

Dierstudies zijn goed voor toxicologisch onderzoek, en daar houdt het helemaal op.

[sensimilla]

En ik ben nou net zo blij dat ik al meer dan 2 maand van het roken van ben ...

[BBD]

Origineel gepost door builderB

Ik heb in een T-nation artikel over de wedstrijd voorbereiding van een missfigure (die overigens behoorlijk diep gaat...) gelezen dat ze voor spotvetverbranding nicotine pleisters gebruikten.

edit: ik heb het gevonden, interessant artikel:
Testosterone Nation - Fat to Figure

Intressant?

De shit die AR over zich heenkreeg vanwege dit artikel was echt heerlijke leedvermaak.