Physically Active People Age More Slowly

**3XL** · 14 February 2008, 18:27

Physically Active People Age More Slowly Physically Active People Age More Slowly

A new study on twins by researchers in the UK showed that people who are physically active in their leisure time aged more slowly than their more sedentary counterparts.

The study is published in the 28th January issue of the Archives of Internal Medicine, and is the work of Dr Lynn F Cherkas, of King's College London, and colleagues.

The researchers noted that previous research had already suggested that:

"A sedentary lifestyle increases the propensity to aging-related disease and premature death."

Regular exercise is linked to lower rates of high blood pressure, heart and circulation problems, type 2 diabetes, cancer, obesity and osteoporosis, they said.

But Cherkas and colleagues suggested their study showed that:

"Inactivity may diminish life expectancy not only by predisposing to aging-related diseases but also because it may influence the aging process itself."

In this study, 2,401 white twins (2,152 women and 249 men) filled in questionnaires about how much they exercised, whether and how much they smoked, and their socioeconomic status. All participants were healthy and they also gave blood samples so that their DNA could be examined.

The researchers were interested in the length of telomere sequences at the ends of the chromosomes in the participants' leukocytes or white blood cells, what they termed the "leukocyte telomere length" or LTL. These tend to get shorter as people age and are used as an indicator of a person's biological age.

To be precise, the researchers defined an LTL measure as the "mean terminal restriction fragment length", which is expressed in terms of structural units called nucleotides.

They found that on average, LTL decreased with age at a loss of 21 nucleotides per year.

After adjusting for age and other potential confounders, such as age, sex, body mass index, smoking, socioeconomic status, and physical activity at work, the results showed that men and women who were less physically active in their leisure time had shorter LTLs than those who were more physically active.

In addition, the results showed that:
The LTLs of the most active participants were 200 nucleotides longer than the least active.

The most active participants performed an average of 199 minutes a week of exercise in their leisure time compared with 16 minutes for the least active.

The link between longer LTLs and physical activity was confirmed by looking at a subset of twins where one was physically active in his or her leisure time and the other was sedentary.

On average, the LTL of the more active twins were 88 nucleotides longer than those of the less active twins.

Cherkas and colleagues concluded that:

"A sedentary lifestyle (in addition to smoking, high body mass index, and low socioeconomic status) has an effect on LTL and may accelerate the aging process."

They suggested this finding showed that "adults who partake in regular physical activity are biologically younger than sedentary individuals" and:

"Provides a powerful message that could be used by clinicians to promote the potentially antiaging effect of regular exercise."

Speculating on the reasons behind this link between longer telomeres and exercise, Cherkas and colleagues suggested that sedentary lifestyles probably increase inflammation and oxidative stress damage to cells.

Perceived stress levels have been linked to telomere length in other studies, and they suggest that by decreasing psychological stress, physical activity mitigates its influence on telomeres and aging.

They went on to point out the importance of following guidelines for physical exercise. The US guidelines for example recommend people have 30 minutes of moderate intensity physical activity on five days every week.

Dr Jack M Guralnik, of the National Institute on Aging, Bethesda, Maryland, USA, said that more research was needed to establish a direct link between aging and physical activity. In an editorial in the same issue of the journal he explained there could be other factors at play:

"Persons who exercise are different from sedentary persons in many ways, and although certain variables were adjusted for in this analysis, many additional factors could be responsible for the biological differences between active and sedentary persons, a situation referred to by epidemiologists as residual confounding."

But he added that:

"Nevertheless, this article serves as one of many pieces of evidence that telomere length might be targeted in studying aging outcomes."

Telomeres are thought to act a like a buffer zone of "useless" DNA on the ends of the DNA strands that protects the integrity of the useful information in our DNA because every time a cell divides and its DNA is copied, it loses some of the edges of the DNA. This is like every time you take a photocopy of a photocopy, the image creeps toward the edges and deteriorates, until eventually you lose the bits around the edge.

"The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length."
Lynn F. Cherkas; Janice L. Hunkin; Bernet S. Kato; J. Brent Richards; Jeffrey P. Gardner; Gabriela L. Surdulescu; Masayuki Kimura; Xiaobin Lu; Tim D. Spector; Abraham Aviv.
Arch Intern Med 2008;168(2):154-158.
Vol. 168 No. 2, January 28, 2008.

Abstract
The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length
Lynn F. Cherkas, PhD; Janice L. Hunkin, BSc; Bernet S. Kato, PhD; J. Brent Richards, MD; Jeffrey P. Gardner, PhD; Gabriela L. Surdulescu, MSc; Masayuki Kimura, MD, PhD; Xiaobin Lu, MD; Tim D. Spector, MD, FRCP; Abraham Aviv, MD

Arch Intern Med. 2008;168(2):154-158.

Background Physical inactivity is an important risk factor for many aging-related diseases. Leukocyte telomere dynamics (telomere length and age-dependent attrition rate) are ostensibly a biological indicator of human aging. We therefore tested the hypothesis that physical activity level in leisure time (over the past 12 months) is associated with leukocyte telomere length (LTL) in normal healthy volunteers.

Methods We studied 2401 white twin volunteers, comprising 2152 women and 249 men, with questionnaires on physical activity level, smoking status, and socioeconomic status. Leukocyte telomere length was derived from the mean terminal restriction fragment length and adjusted for age and other potential confounders.

Results Leukocyte telomere length was positively associated with increasing physical activity level in leisure time (P < .001); this association remained significant after adjustment for age, sex, body mass index, smoking, socioeconomic status, and physical activity at work. The LTLs of the most active subjects were 200 nucleotides longer than those of the least active subjects (7.1 and 6.9 kilobases, respectively; P = .006). This finding was confirmed in a small group of twin pairs discordant for physical activity level (on average, the LTL of more active twins was 88 nucleotides longer than that of less active twins; P = .03).

Conclusions A sedentary lifestyle (in addition to smoking, high body mass index, and low socioeconomic status) has an effect on LTL and may accelerate the aging process. This provides a powerful message that could be used by clinicians to promote the potentially antiaging effect of regular exercise.

Author Affiliations: Twin Research and Genetic Epidemiology Unit, King's College London, St Thomas' Hospital Campus, London, England (Drs Cherkas, Kato, Richards, and Spector and Mss Hunkin and Surdulescu); and The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark (Drs Gardner, Kimura, Lu, and Aviv).

**Big T** · 15 February 2008, 08:47

Ik dacht altijd dat vrije radicalen (verantwoordelijk voor schade aan cellen) meer vrijkwamen bij meer fysieke activiteit. Maar blijkt dus niet zo van belang. Mooi dit, 35+ die meer bewegen/fitnessen/bb zien er idd veel langer veel beter/minder oud uit!

diky · 15 February 2008, 14:23

Citaat:

Origineel gepost door 3XL

They went on to point out the importance of following guidelines for physical exercise. The US guidelines for example recommend people have 30 minutes of moderate intensity physical activity on five days every week.

Niet te vroeg juichen Big_T....

....BB's en andere krachtsporters trainen doorgaans langer en met een hoge intensiteit. Ik denk dat hier andere meetresultaten uit te voorschijn zullen komen en het verhaal van de vrije radicalen wel eens bewaarheid kan worden.

**3XL** · 15 February 2008, 18:47

je moet de pos. effecten van de training afzetten tegen de extra aanmaak van vrije radicalen en dan denk ik dat het pos. effect het negative opheft en voorbijgaat.

diky · 16 February 2008, 13:10

@3XL, daar gokken we dan maar op....

**RougeMonkey** · 16 February 2008, 13:12

Citaat:

Origineel gepost door diky

Niet te vroeg juichen Big_T....

....BB's en andere krachtsporters trainen doorgaans langer en met een hoge intensiteit. Ik denk dat hier andere meetresultaten uit te voorschijn zullen komen en het verhaal van de vrije radicalen wel eens bewaarheid kan worden.

Idd. Er is een verschill tussen physically active en bodybuilding

.

**Big T** · 16 February 2008, 13:43

Zou wel eens mooi zijn als ze dit ook eens bekijken voor bb. Maar zeg nu zelf: mensen die blijven bb op oudere leeftijd zien er toch ook veel beter en jonger uit. Zolang je jezelf maar niet in een chemische fabriek verandert.

jacky den bels · 16 February 2008, 15:18

als ik naar de meeste van mijn leeftijdsgenoten kijk die niets doen dan zie ik het verschil toch duidelijk hahahahaha en dat zijn ook nog net de mensen dieme voor gek verklaren dat ik zo vaak ga sporten.....

Lukie · 17 February 2008, 12:54

Jackie,
sporten gaat de veroudering tegen en is goed voor de bloedsomloop
wij sporters zijn de beste

**Jizza** · 22 February 2008, 14:17

Jeeeeej, ik word een lekkere opa!

Dat wordt solliciteren: Welcome to Oldje.com

Tjooky · 29 March 2008, 13:35

viagra!!!!!!!!!!!!

jacky den bels · 29 March 2008, 17:43

wie viagra?? hehehe

Lukie · 30 March 2008, 12:46

Jackie ik heb DIT niet nodig hé mate
WAZAHHHHHHHHHHHHHHHHHHHHHH

14 February 2008, 18:27	#1
3XL Super Moderator Geregistreerd: Apr 2002 Locatie: افغانستان Geslacht: V Posts: 10.504 Karma Power: 26	Physically Active People Age More Slowly Physically Active People Age More Slowly Physically Active People Age More Slowly A new study on twins by researchers in the UK showed that people who are physically active in their leisure time aged more slowly than their more sedentary counterparts. The study is published in the 28th January issue of the Archives of Internal Medicine, and is the work of Dr Lynn F Cherkas, of King's College London, and colleagues. The researchers noted that previous research had already suggested that: "A sedentary lifestyle increases the propensity to aging-related disease and premature death." Regular exercise is linked to lower rates of high blood pressure, heart and circulation problems, type 2 diabetes, cancer, obesity and osteoporosis, they said. But Cherkas and colleagues suggested their study showed that: "Inactivity may diminish life expectancy not only by predisposing to aging-related diseases but also because it may influence the aging process itself." In this study, 2,401 white twins (2,152 women and 249 men) filled in questionnaires about how much they exercised, whether and how much they smoked, and their socioeconomic status. All participants were healthy and they also gave blood samples so that their DNA could be examined. The researchers were interested in the length of telomere sequences at the ends of the chromosomes in the participants' leukocytes or white blood cells, what they termed the "leukocyte telomere length" or LTL. These tend to get shorter as people age and are used as an indicator of a person's biological age. To be precise, the researchers defined an LTL measure as the "mean terminal restriction fragment length", which is expressed in terms of structural units called nucleotides. They found that on average, LTL decreased with age at a loss of 21 nucleotides per year. After adjusting for age and other potential confounders, such as age, sex, body mass index, smoking, socioeconomic status, and physical activity at work, the results showed that men and women who were less physically active in their leisure time had shorter LTLs than those who were more physically active. In addition, the results showed that: The LTLs of the most active participants were 200 nucleotides longer than the least active. The most active participants performed an average of 199 minutes a week of exercise in their leisure time compared with 16 minutes for the least active. The link between longer LTLs and physical activity was confirmed by looking at a subset of twins where one was physically active in his or her leisure time and the other was sedentary. On average, the LTL of the more active twins were 88 nucleotides longer than those of the less active twins. Cherkas and colleagues concluded that: "A sedentary lifestyle (in addition to smoking, high body mass index, and low socioeconomic status) has an effect on LTL and may accelerate the aging process." They suggested this finding showed that "adults who partake in regular physical activity are biologically younger than sedentary individuals" and: "Provides a powerful message that could be used by clinicians to promote the potentially antiaging effect of regular exercise." Speculating on the reasons behind this link between longer telomeres and exercise, Cherkas and colleagues suggested that sedentary lifestyles probably increase inflammation and oxidative stress damage to cells. Perceived stress levels have been linked to telomere length in other studies, and they suggest that by decreasing psychological stress, physical activity mitigates its influence on telomeres and aging. They went on to point out the importance of following guidelines for physical exercise. The US guidelines for example recommend people have 30 minutes of moderate intensity physical activity on five days every week. Dr Jack M Guralnik, of the National Institute on Aging, Bethesda, Maryland, USA, said that more research was needed to establish a direct link between aging and physical activity. In an editorial in the same issue of the journal he explained there could be other factors at play: "Persons who exercise are different from sedentary persons in many ways, and although certain variables were adjusted for in this analysis, many additional factors could be responsible for the biological differences between active and sedentary persons, a situation referred to by epidemiologists as residual confounding." But he added that: "Nevertheless, this article serves as one of many pieces of evidence that telomere length might be targeted in studying aging outcomes." Telomeres are thought to act a like a buffer zone of "useless" DNA on the ends of the DNA strands that protects the integrity of the useful information in our DNA because every time a cell divides and its DNA is copied, it loses some of the edges of the DNA. This is like every time you take a photocopy of a photocopy, the image creeps toward the edges and deteriorates, until eventually you lose the bits around the edge. "The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length." Lynn F. Cherkas; Janice L. Hunkin; Bernet S. Kato; J. Brent Richards; Jeffrey P. Gardner; Gabriela L. Surdulescu; Masayuki Kimura; Xiaobin Lu; Tim D. Spector; Abraham Aviv. Arch Intern Med 2008;168(2):154-158. Vol. 168 No. 2, January 28, 2008. Abstract The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length Lynn F. Cherkas, PhD; Janice L. Hunkin, BSc; Bernet S. Kato, PhD; J. Brent Richards, MD; Jeffrey P. Gardner, PhD; Gabriela L. Surdulescu, MSc; Masayuki Kimura, MD, PhD; Xiaobin Lu, MD; Tim D. Spector, MD, FRCP; Abraham Aviv, MD Arch Intern Med. 2008;168(2):154-158. Background Physical inactivity is an important risk factor for many aging-related diseases. Leukocyte telomere dynamics (telomere length and age-dependent attrition rate) are ostensibly a biological indicator of human aging. We therefore tested the hypothesis that physical activity level in leisure time (over the past 12 months) is associated with leukocyte telomere length (LTL) in normal healthy volunteers. Methods We studied 2401 white twin volunteers, comprising 2152 women and 249 men, with questionnaires on physical activity level, smoking status, and socioeconomic status. Leukocyte telomere length was derived from the mean terminal restriction fragment length and adjusted for age and other potential confounders. Results Leukocyte telomere length was positively associated with increasing physical activity level in leisure time (P < .001); this association remained significant after adjustment for age, sex, body mass index, smoking, socioeconomic status, and physical activity at work. The LTLs of the most active subjects were 200 nucleotides longer than those of the least active subjects (7.1 and 6.9 kilobases, respectively; P = .006). This finding was confirmed in a small group of twin pairs discordant for physical activity level (on average, the LTL of more active twins was 88 nucleotides longer than that of less active twins; P = .03). Conclusions A sedentary lifestyle (in addition to smoking, high body mass index, and low socioeconomic status) has an effect on LTL and may accelerate the aging process. This provides a powerful message that could be used by clinicians to promote the potentially antiaging effect of regular exercise. Author Affiliations: Twin Research and Genetic Epidemiology Unit, King's College London, St Thomas' Hospital Campus, London, England (Drs Cherkas, Kato, Richards, and Spector and Mss Hunkin and Surdulescu); and The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark (Drs Gardner, Kimura, Lu, and Aviv). __________________ As you are now, I once was. As I am now, you'll never be ©3XL ®2000 The only easy day was yesterday...............Life is hard, so am I Doing more exercise with less intensity has all but destroyed the actual great value of weight training. Something must be done . . . and quickly." (," Arthur Jones) Geloof niets, probeer alles

15 February 2008, 08:47	#2
Big T Super Administrator Geregistreerd: Oct 2002 Locatie: In de Gym Geslacht: M Posts: 29.830 Karma Power: 60	Ik dacht altijd dat vrije radicalen (verantwoordelijk voor schade aan cellen) meer vrijkwamen bij meer fysieke activiteit. Maar blijkt dus niet zo van belang. Mooi dit, 35+ die meer bewegen/fitnessen/bb zien er idd veel langer veel beter/minder oud uit! __________________ Graag geen vragen mbt bb via pm Train like an animal, eat like a horse, sleep like a baby, grow like a weed Doe Mee aan de Grote Tevredenheids Enquête

15 February 2008, 18:47	#4
3XL Super Moderator Geregistreerd: Apr 2002 Locatie: افغانستان Geslacht: V Posts: 10.504 Karma Power: 26	je moet de pos. effecten van de training afzetten tegen de extra aanmaak van vrije radicalen en dan denk ik dat het pos. effect het negative opheft en voorbijgaat. __________________ As you are now, I once was. As I am now, you'll never be ©3XL ®2000 The only easy day was yesterday...............Life is hard, so am I Doing more exercise with less intensity has all but destroyed the actual great value of weight training. Something must be done . . . and quickly." (," Arthur Jones) Geloof niets, probeer alles

16 February 2008, 13:10	#5
diky Advanced Bodybuilder Geregistreerd: Aug 2004 Locatie: Nederland Geslacht: M Posts: 1.311 Karma Power: 7	@3XL, daar gokken we dan maar op.... __________________ "Less is more"

16 February 2008, 13:43	#7
Big T Super Administrator Geregistreerd: Oct 2002 Locatie: In de Gym Geslacht: M Posts: 29.830 Karma Power: 60	Zou wel eens mooi zijn als ze dit ook eens bekijken voor bb. Maar zeg nu zelf: mensen die blijven bb op oudere leeftijd zien er toch ook veel beter en jonger uit. Zolang je jezelf maar niet in een chemische fabriek verandert. __________________ Graag geen vragen mbt bb via pm Train like an animal, eat like a horse, sleep like a baby, grow like a weed Doe Mee aan de Grote Tevredenheids Enquête

16 February 2008, 15:18	#8
jacky den bels Colossal Veteran Geregistreerd: Apr 2006 Locatie: waar mijn bed slaapt; neerpelt dus Leeftijd: 42 Geslacht: M Posts: 13.693 Karma Power: 60	als ik naar de meeste van mijn leeftijdsgenoten kijk die niets doen dan zie ik het verschil toch duidelijk hahahahaha en dat zijn ook nog net de mensen dieme voor gek verklaren dat ik zo vaak ga sporten..... __________________ Alles komt goed :zo niet dan toch meet in valkenswaard 14 juni pm me voor bankrekeningnr: Nog 16 dagen om te betalen

17 February 2008, 12:54	#9
Lukie Cool Novice Geregistreerd: Oct 2007 Locatie: België Leeftijd: 51 Geslacht: M Posts: 242 Karma Power: 1	Jackie, sporten gaat de veroudering tegen en is goed voor de bloedsomloop wij sporters zijn de beste

22 February 2008, 14:17	#10
Jizza Bajes Beest Geregistreerd: May 2005 Locatie: Haarlem Leeftijd: 24 Geslacht: M Posts: 4.185 Karma Power: 33	Jeeeeej, ik word een lekkere opa! Dat wordt solliciteren: Welcome to Oldje.com __________________ Buk... en gij zult voelen Trainingslog: http://www.jhuchshorn.blogspot.com Progressiefoto's: http://forum.dutchbodybuilding.com/f...-jizza-133522/

29 March 2008, 13:35	#11
Tjooky Competitive Bodybuilder Geregistreerd: Jun 2007 Locatie: Nederland Leeftijd: 24 Geslacht: M Posts: 2.778 Karma Power: 15	viagra!!!!!!!!!!!! __________________ 188 96 kilo 24 jaar vet (te vet) En deze jongen weet waar hij het over heeft hoor: Bosje "In jouw schuild een kleine ronnie coleman dat een ding wat ccker is 8 van mij"

29 March 2008, 17:43	#12
jacky den bels Colossal Veteran Geregistreerd: Apr 2006 Locatie: waar mijn bed slaapt; neerpelt dus Leeftijd: 42 Geslacht: M Posts: 13.693 Karma Power: 60	wie viagra?? hehehe __________________ Alles komt goed :zo niet dan toch meet in valkenswaard 14 juni pm me voor bankrekeningnr: Nog 16 dagen om te betalen

30 March 2008, 12:46	#13
Lukie Cool Novice Geregistreerd: Oct 2007 Locatie: België Leeftijd: 51 Geslacht: M Posts: 242 Karma Power: 1	Jackie ik heb DIT niet nodig hé mate WAZAHHHHHHHHHHHHHHHHHHHHHH

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