Cholesterol en hart- en vaatziekten

[MeDieViL]

thx, daar was ik niet van op de hoogte

hmm, ik hoor juist op het nieuws dat becel pro actif producten worden terugbetaald, het onderzoek dat aantoond dat plantensterolen hartziekten verminderen ontgaat mij...

[Robjee]

Er is volgens mij geen onderzoek dat direct laat zien dat plantensterolen en/of –stanolen hartziekten verminderd.
Het product is beoordeeld op de totaal- en LDL-cholesterolverlagende werking ervan. Vanuit deze werking is waarschijnlijk geacht dat het hartziekten kan verminderen.
Wel is rekening gehouden met eventueel mogelijke negatieve gezondheidseffecten. Het serum carotenoïden zou namelijk dalen. De cholesterolverlagende werking van de plantensterolen weegt echter op tegen deze mogelijk daling, volgens de ondergetekenden.
http://www.voedingscentrum.nl/NR/rdo...roactivpdf.pdf

[Big T]

Bij dat nieuwsbericht had ik echt zoiets van ga eens je algemene voeding en levenswijze aanpassen ipv die plantensterolenonzin te steunen. Alsof één product in die hoeveelheid kan goedmaken wat je verder allemaal verkeerd doet. Op de verpakking is vermeld 'bevat omega 3' ik vraag me echt af hoeveel dat beetje gaat uitmaken. Je kan wel zien dat de samenwerking van het ziekenfonds en Becel vooral commercieel gezien een leuke deal was. Mensen vertrouwen hun ziekenfonds en het feit dat dit op tv komt is voor velen reden genoeg om te denken dat het een snelle oplossing is, welke medicijnen of verdere aanpassing van voedingspatroon en levenswijze overbodig zou maken.

[MeDieViL]

Dit is een intressante site van Uffe Ravnskov, toch niet een van de minste!
http://www.ravnskov.nu/cholesterol.htm


http://qjmed.oxfordjournals.org/cgi/...tE&keytype=ref

according to Uffe Ravsnkov (The cholesterol myths) Framingham actually states that lowering your cholesterol by 1 mg /dl leads to a mortaility increase of 11%

hmm..

[MeDieViL]

Juist een interessante post gelezen van dr eades

Hi Cathy--

Here is what the 'real' data say about cholesterol. There seems to be no relation to total cholesterol and mortality in women of all ages except for women over 50. In women over 50 there appears to be some protective effect with higher cholesterol levels. And if total cholesterol is high because it is made up of a lot of HDL, who cares?

As you know from reading this blog, I'm not a real believer in the lipid hypothesis of heart disease. Having said that, if there is any part of the whole hypothesis that I think is even part way valid it would be that HDL cholesterol is protective. And probably that small, dense LDL is more easily oxidized and may contribute to cardiovascular disease. It's obvious that your HDL cholesterol is high, very high, in fact, so this should be protective.

You can go to the trouble and expense (it cost about $200 the last time I checked) to get your LDL analyzed as to particle size. There have been enough studies done now showing that triglycerides are a surrogate marker for LDL particle size--high triglycerides indicate small dense LDL; low triglycerides mean large fluffy, type A, LDL--that I don't bother with the expensive test any longer. I simply look at triglycerides, and yours are certainly low. (You could request an ApoB test, which will show how many LDL particles you have; if there aren't very many and you have a lot of LDL, then you'll know that the particle size is large. ApoB is a less costly lab test than the direct measurement of particle size.) Even the folks who are firm believers in the LDL-cholesterol-is-bad theory, don't particularly fear the large type A LDL particles.

I'm sure Eric Westman or Bill Yancey (they work together) would be interested in your case. I know them both. Tell them I suggested you contact them. They are both extremely nice and both are experienced with low-carb diets.

Good luck. Keep me posted.

Ik heb nu op het protein forum een post gemaakt waar ik naar die studies vraag over triglyceriden, ik hou jullie op de hoogte

[MeDieViL]

Dit heb ik zover

Change in LDL particle size is associated with change in plasma triglyceride concentration.

McNamara JR, Jenner JL, Li Z, Wilson PW, Schaefer EJ.

Lipid Metabolism Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Mass. 02111.

Low density lipoprotein (LDL) particle size is inversely associated with plasma triglyceride concentration in cross-sectional analyses. In the present study, changes in the LDL particle size of 227 participants of the Framingham Offspring Study were analyzed longitudinally by nondenaturing gradient gel electrophoresis at two examinations that were separated by 3-4 years. All subjects had triglyceride concentrations < 400 mg/dl at both exams. Using laser scanning densitometry to assess mean LDL particle size, 56% of samples displayed a change in size: 41% had a one-band size change, 13% had a two-band change, and 2% had a three-band change. These changes in size corresponded to a 15% change in pattern type, based on pattern A and B terminology. There was a significant inverse association between change in LDL size and change in triglyceride (p < 0.0001) and glucose (p < 0.004) concentrations, body weight (p < 0.02), and age (p < 0.03). There was also a significant positive association with change in high density lipoprotein (HDL) cholesterol concentration (p < 0.0001). Change in LDL cholesterol concentration, as calculated by use of the Friedewald formula, however, showed no significant association with change in LDL size (p < 0.9). There was also no significant association with change in smoking or blood pressure, but there was a nonsignificant inverse trend associated with alcohol intake (p < 0.08).(ABSTRACT TRUNCATED AT 250 WORDS)

A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction.

Stampfer MJ, Krauss RM, Ma J, Blanche PJ, Holl LG, Sacks FM, Hennekens CH.

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA.

OBJECTIVE: To test whether a predominance of small, dense low-density lipoprotein (LDL) particles and elevated triglyceride levels are independent risk factors for myocardial infarction (MI). DESIGN: Nested case-control study with prospectively collected samples. SETTING: Prospective cohort study. PARTICIPANTS: Blood samples were collected at baseline (85% nonfasting samples) from 14916 men aged 40 to 84 years in the Physicians' Health Study. MAIN OUTCOME MEASUREMENTS: Myocardial infarction diagnosed during 7 years of follow-up. RESULTS: Cases (n=266) had a significantly smaller LDL diameter (mean [SD], 25.6 [0.9] nm) than did controls (n=308) matched on age and smoking (mean [SD], 25.9 [8] nm; P<.001). Cases also had higher median triglyceride levels (1.90 vs 1.49 mmol/L [168 vs 132 mg/dL]; P<.001). The LDL diameter had a high inverse correlation with triglyceride level (r=-0.71), and a high direct correlation with high-density lipoprotein cholesterol (HDL-C) level (r=0.60). We observed a significant multiplicative interaction between triglyceride and total cholesterol (TC) levels (P=.01). After simultaneous adjustment for lipids and a variety of coronary risk factors, LDL particle diameter was no longer a statistically significant risk indicator, with a relative risk (RR) of 1.09 (95% confidence interval [CI], 0.85-1.40) per 0.8-nm decrease. However, triglyceride level remained significant with an RR of 1.40 (95% CI, 1.10-1.77) per 1.13 mmol/L (100-mg/dL) increase. The association between triglyceride level and MI risk appeared linear across the distribution; men in the highest quintile had a risk about 2.5 times that of those in the lowest quintile. The TC level, but not HDL-C level, also remained significant, with an RR of 1.80 (95% CI, 1.44-2.26) per 1.03-mmol/L (40-mg/dL) increase. CONCLUSIONS: These findings indicate that nonfasting triglyceride levels appear to be a strong and independent predictor of future risk of MI, particularly when the total cholesterol level is also elevated. In contrast, LDL particle diameter is associated with risk of MI, but not after adjustment for triglyceride level. Increased triglyceride level, small LDL particle diameter, and decreased HDL-C levels appear to reflect underlying metabolic perturbations with adverse consequences for risk of MI; elevated triglyceride levels may help identify high-risk individuals.

[EricR]

Over de beginpost, ik zou Mary Enig nooit als expert opvoeren op het gebied van dit soort zaken. Ze heeft dan wel veel geschreven over vetten, voeding etc maar ze is geen echte wetenschapper. Haar bijdragen aan de wetenschap zijn beperkt tot wat nietszeggende onderzoeken en voor de rest gaat ze vrij selectief te werk in het publiceren van resultaten van onderzoeken.

En dan Ravnskov die zou (met de nadruk op zou) ooit onderzoeksresultaten vervalst hebben en daarom ontslagen zijn bij de universiteit waar hij werkte. Lijkt me ook niet echt een goede referentie.

[hompie]

Hallo,

Mijn cholesterol was 6.8. Eigenlijk is het mijn hele leven nooit echt laag geweest en het zit een beetje in de familie. Mijn ldl was 5.5 en hdl 0.8.
Wat ik begreep is dat deze verhouding niet echt goed was en de dokter heeft op mijn aandringen Lipitor gegeven.
Me ldl is gezakt naar 3,4 me hdl is hetzelfde gebleven, me ratio is dus wel een stuk beter geworden.
Maar nu ben ik in de war kan ik me Lipitor beter weg gooien?
Ik dacht dat ik nu minder kans had op een hartaanval maar dat is dus niet zo