Mgf

[IKKE]

Je IGF-1 dosis kan iets lager zijn dan normaal. Dus niet veel duurder dan igf-1 only.

[superspider]

Die opgezette buik door igf-1 testo

[IKKE]

Origineel gepost door superspider

Die opgezette buik door igf-1 testo

Ga even meer lezen gozer.
Wat je zegt is niet waar.

Dat is bij extreme doseringen HGH+IGF-1 + INSULIINE

En dan heb ik het over 20 i.u. hgh per dag + 40 iu korte insuline + berg langwerkende. etc.

[superspider]

owzow, dus een iets lagere dosis igf-1 en een normale dosis mgf hebben dus bijna geen nawerkingen?

[enrico]

nu kan ik compleet verkeerd zijn, maar als ik het zo lees, is die kortwerkende mgf dan niet effectiever icm ifg-1 dan dat de langwerkende dat zou zijn?(rekeninghoudend met dat grafiekje)

als ik nu verschrikkelijk dom overkom, vergeef me, het is al laat

[loekie]

Is er al iets bekend over of het echt WERKT? toch het belangrijkste van allemaal. Zijn er "voor" en "na" fotos?

[klaas]

Origineel gepost door loekie

Is er al iets bekend over of het echt WERKT? toch het belangrijkste van allemaal. Zijn er "voor" en "na" fotos?

nee zullen ook geen voor en na fotos van igf zijn...is meer een subtiel iets..

[loekie]

Origineel gepost door klaas

nee zullen ook geen voor en na fotos van igf zijn...is meer een subtiel iets..

dus er hoeft geen redelijk zichtbare toename van bijv. de kuit verwacht te worden?

[IKKE]

Het zorgt voor meer lokale spiergroei.

Ik hoop het deze week binnen te krijgen...
dus pakken we meetlintje erbij

[loekie]

Origineel gepost door IKKE

Het zorgt voor meer lokale spiergroei.

Ik hoop het deze week binnen te krijgen...
dus pakken we meetlintje erbij

ben benieuwd, succes!!

[IKKE]

Van een gozer die samenwerkt met de makers van MGF (IBE)


Quick summary: MGF is a splice variant of the IGF produced by a frame shift if the IGF gene. It exhibits local effects in skeletal muscle and without modification is not systemic (can’t travel through the body). MGF increase the muscle stem cell count, so that more may fuse and become part of adult muscle cells. This is a process required for adult muscle cells to continue growing.

Complete Overview of MGF or IGF-IEc

From its sequence, MGF is derived from the IGF-I gene by alternative splicing and has different 3' exons to the liver or systemic type (IGF-IEa). It has a 49 base pair insert in the human, and a 52 base pair insert in rodents, within the E domain of exon 5. This insert results in a reading frame shift, with a different carboxy (C) terminal sequence to that of systemic IGF-IEa. MGF and the other IGF isoforms have the same 5' exons that encode the IGF-I ligand-binding domain. Processing of pro-peptide yields a mature peptide that is involved in upregulating protein synthesis. However, there is evidence that the carboxy-terminal of the MGF peptide also acts as a separate growth factor. This stimulates division of mononucleated myoblasts or satellite (stem) cells, thereby increasing the number available for local repair

During the early stage of skeletal muscle development, myoblasts (muscle stem cells) fuse to form syncytial myotubes, which become innervated and develop into muscle fibres. Thereafter, mitotic proliferation of nuclei within the muscle fibres ceases. However, during postnatal (after development) growth, additional nuclei are provided by satellite cells (myoblast) fusing with myotubules. Muscle damage-recovery seems to have a similar cellular mechanism, in that satellite cells become activated and fuse with the damaged muscle fibres (reviewed by Goldring et al. 2002). This is also pertinent to certain diseases such as muscular dystrophy in which muscle tissue is not maintained and which have been associated with a deficiency in active satellite (stem) cells (Megeney et al. 1996; Seale & Rudnicki, 2000) and in myogenic factors (Heslop et al. 2000). Skeletal muscle mass and regenerative capacity have also been shown to decline with age (Sadeh, 1988; Carlson et al. 2001). The reduced capacity to regenerate in older muscle seems to be due to the decreased ability to activate satellite cell proliferation (Chakravarthy et al. 2000). The markedly lower expression of MGF in older rat muscles (Owino et al. 2001) and human muscle (Hameed et al. 2003) in response to mechanical overload has been associated with the failure to activate satellite cells, leading to age-related muscle loss (Owino et al. 2001). Your muscle cels can not grow once they have reached a certain size unless they obtain more nuclei from the myoblast. MGF increases the myblast available to donate their nuclei to the adult muscle cell.
“MGF appears to have a dual action in that, like the other IGF-I isoforms, it upregulates protein synthesis as well as activating satellite cells. However, the latter role of MGF is probably more important as most of the mature IGF-I will be derived from IGF-IEa during the second phase of repair. Nevertheless, it has been shown that MGF is a potent inducer of muscle hypertrophy in experiments in which the cDNA of MGF was inserted into a plasmid vector and introduced by intramuscular injection. This resulted in a 20 % increase in the weight of the injected muscle within 2 weeks, and the analyses showed that this was due to an increase in the size of the muscle fibres (Goldspink, 2001). Similar experiments by other groups have also been carried out using a viral construct containing the liver type of IGF-I, which resulted in a 25 % increase in muscle mass, but this took over 4 months to develop (Musaro et al. 2001). Hence, the dual role MGF plays in inducing satellite cell activation as well as protein synthesis suggests it is much more potent than the liver type or IGF-IEa for inducing rapid hypertrophy.”

These results are based on actual transplantation of the DNA coding for the peptides. This is a permanent effect and much more potent than IM injections of the peptide itself. You will not see a 20% increase in muscle mass through IM injections as claimed above.


Methods of use:

MGF inhibits differentiation, which is the actual fusing of the myoblast to the myotubule. So to optimize the effects of this one would want to try and take the MGF in a manner that differentiation would not be effected post work out.
With the original version of MGF, it is only stable in your system for 12-24 hours. So taking it the day before a workout would provide sufficient time for the MGF to wear off.

If one wanted to maximize the effects of MGF they could stack it with something that increased differentiation. In the case of IGF, the would want to take this on days they don't take MGF, or in the case of AAS it would depend on the types of AAS and the esters.

Some sample MGF/IGF protocols

3 day HST method
MGF sun, tue, thur
IGF mon tue wed (workout days)

4 day split
Sun MGF upper body
Monday MGF lower body IGF upper body
Tue IGF lower body
Repeat thur/fri

5 day split
B/C MGF is not stable in the bloodstream, it will not effect the muscle you don't inject. So as long as you are using the original MGF you could inj MGF and IGF on the same days without worrying about conflicts b/t the peptides.
Just inj the MGF in the muscle you will owrk the following day.

[G21]

@ ikke... je hebt de regular versie besteld toch? hoeveel mcg ga je per spiergroep zetten?

[IKKE]

Origineel gepost door G21

@ ikke... je hebt de regular versie besteld toch? hoeveel mcg ga je per spiergroep zetten?

Dat ben ik nog aan het uitzoeken.


heb jij eventuele inspiratie:

Wat ik zie is 100 mcg per plek wel optimaal ?

[G21]

ik denk dat het afhangt aan je trainings routine..ga je een split doen of hst zoals thegame?

ik denk dat je zou kunnen starten met 50mcg per bodypart, en dit een dag of 10 aankijken...eventueel dosering verhogen..ik geloof dat die gast 33mcg per spiergroep doet..

ga je het volgens zijn protocol doen? avond voor training in de te trainen spiergroep zetten, en vervolgens pwo igf?

ben erg benieuwd..

[IKKE]

ik wil timing protocool wel volgens ja.

Ik denk dat ik eerst even beperk tot 2 kleine spiergroepen om te kijken wat het doet voor lokale spiergroei

denk biceps en kuiten...vooral kuiten vind ik interessant..lopen bij veel mensen achter..bij mij ook een beetje

Eerst nog wachten totdat pakketje aankomt!

[G21]

waiting is a bitch!!

[klaas]

Here is an example on how I ( myself )would use it, let's say I want bring out more size to my delts and pecs and I work out 5X per week as follows:

monday : chest
tuesday: back
wed: legs
thurs: shoulders
friday: arms

I have 2 vials of 2mgs of MGF and 1 vial of 1mg of IGF-1Lr3
4000mcgs MGF
1000mchs IGF-1Lr3

I dilute one vial of MGF with 2mls of sterile water and place the other vial ( powder/not diluted ) in the fridge.
I will use 1ml of AA for my IGF-1

I proceed to use these two for a period of 4 weeks.

Based on my training schedule I'd apply these as follows:

sunday night : I'd inject 250mcgs on each pec ( left and right )
monday 10am : train chest and inject 60mcgs of IGF-1Lr3 ( at least ) post work out on both left and right pecs

tuesday: train back and inject IGF-1 60mcgs post work out on left and right pecs

wednesday: train legs and inject IGF-1 60mcgs post work out on left and right pecs
wednesday night: inject 250mcgs of MGF in left and right delt (each 250mcgs )

thursday 10am: train delts and inject 60mcgs IGF-1 post work out in right and left delts

friday 10am: train arms and inject IGF-1 post work out in left and right delts.

saturday : off ( maybe do one hour cardio in addition to my ED 30minute cardio session post weight lifting exercise )

sunday: repeat again

This first vial of MGF will be finished in week#2 so the other vial will need to be diluted with sterile water to continue.

Please note that one may work on more than two muscles groups at a time and the dosages do not have to be 1000mcgs /week but I believe this may be effective, same goes with the IGF-1.

Before the haters post their hateful attacks on me I want to clearly state the above is based on my own coclusions and interpretations, by no means the sample protocol posted above is the most appropiate way of stacking MGF and IGF-1, is just my how I'd cycle these peptides.

You guys make your own decision.

[klaas]

is deze cycle hierboven niks? klinkt wel grappig...

[BassD]

250mcg on each pec !

beetje weinig vind je niet......

[klaas]

mwaa 2x per week...mgf-burst