Had het een of ander gelezen over clenbuterol, en uit studies is gebleken dat clenbuterol ervoor zorgt dat taurine word verbruikt. En taurine zorgt ervoor dat je cholesterol vloeibaar blijft. Wat beter voor je lichaam is, maar dat wisten we natuurlijk al.
Nu schijnt een supplementatie van 10 gram taurine per dag goed te helpen je hart te beschermen als je clenbuterol neemt.
Je hebt ook vaak last van spierkrampen dit is ook zo goed als weg als je genoeg taurine neemt.
Heart Vessels: 2005 Nov;20(6):278-85.
Taurine prevents myocardial ischemia/reperfusion-induced oxidative stress and apoptosis in prolonged hypothermic rat heart preservation.Oriyanhan W, Yamazaki K, Miwa S, Takaba K, Ikeda T, Komeda M.
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawara-machi, Sakyo-ku, Kyoto 606-8507, Japan.
Taurine (2-aminoethanesulfonic acid) is a potent antioxidant and inhibits cell apoptosis in ischemic reperfusion injury. In this study we evaluated whether addition of taurine to St. Thomas' cardioplegic solution enhances its myocardial protective effects in prolonged hypothermic heart preservation in rats. Hearts isolated from male Sprague-Dawley rats were mounted on a Langendorff apparatus to estimate baseline cardiac function, then arrested and stored in St. Thomas' cardioplegic solution, with taurine (10 mM; taurine group, n = 8) or without taurine (control group, n = 8), for 6 h at 4 degrees C. After storage, the hearts were reperfused and heart rate (HR), coronary flow (CF), left ventricular developed pressure (LVP), and positive maximum left ventricular developing pressure (max LV dp/dt) were measured. The LV tissue was examined immunohistochemically for determining DNA oxidative stress and cell apoptosis. Compared with control groups, recovery of LVP (P < 0.001), max LV dp/dt (P < 0.001), and coronary flow (P < 0.001) were significantly enhanced, whereas glutamic oxaloacetic transaminase (P < 0.01), lactate dehydrogenase (P < 0.05), creatine phosphate kinase (P < 0.01), 8-hydroxy-2'-deoxyguanosine index (P < 0.01), caspase-3 mRNA expression (P < 0.05), and percentage of TUNEL-positive cardiomyocytes (P < 0.05) were reduced in the taurine group. Addition of taurine to St. Thomas' cardioplegic solution improved cardiac function recovery for prolonged hypothermic rat heart preservation by suppressing DNA oxidative stress and cell apoptosis.
PMID: 16314910 [PubMed - in process]
J Pharm Pharmacol: 2005 Oct;57(10):1313-7.
Protective effect of taurine on myocardial antioxidant status in isoprenaline-induced myocardial infarction in rats.Shiny KS, Kumar SH, Farvin KH, Anandan R, Devadasan K.
Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO) Cochin-682029, India.
We have examined the protective effect of taurine on the myocardial antioxidant defense system in isoprenaline (isoproterenol)-induced myocardial infarction in rats, an animal model of myocardial infarction in man. Levels of diagnostic marker enzymes in plasma, lipid peroxides and reduced glutathione, and the activity of glutathione-dependent antioxidant enzymes and anti-peroxidative enzymes in the heart tissue were determined. Intraperitoneal administration of taurine significantly prevented the isoprenaline-induced increases in the levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase in the plasma of rats. Taurine exerted an antioxidant effect against isoprenaline-induced myocardial infarction by preventing the accumulation of lipid peroxides and by maintaining the level of reduced glutathione and the activity of glutathione peroxidase, glutathione-S-transferase, catalase and superoxide dismutase at near normality. The results indicated that the cardioprotective potential of taurine was probably due to the increase of the activity of the free radical enzymes, or to a counteraction of free radicals by its antioxidant nature, or to a strengthening of myocardial membrane by its membrane stabilizing property.
PMID: 16259760 [PubMed - indexed for MEDLINE]
Nu schijnt een supplementatie van 10 gram taurine per dag goed te helpen je hart te beschermen als je clenbuterol neemt.
Je hebt ook vaak last van spierkrampen dit is ook zo goed als weg als je genoeg taurine neemt.
Heart Vessels: 2005 Nov;20(6):278-85.
Taurine prevents myocardial ischemia/reperfusion-induced oxidative stress and apoptosis in prolonged hypothermic rat heart preservation.Oriyanhan W, Yamazaki K, Miwa S, Takaba K, Ikeda T, Komeda M.
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawara-machi, Sakyo-ku, Kyoto 606-8507, Japan.
Taurine (2-aminoethanesulfonic acid) is a potent antioxidant and inhibits cell apoptosis in ischemic reperfusion injury. In this study we evaluated whether addition of taurine to St. Thomas' cardioplegic solution enhances its myocardial protective effects in prolonged hypothermic heart preservation in rats. Hearts isolated from male Sprague-Dawley rats were mounted on a Langendorff apparatus to estimate baseline cardiac function, then arrested and stored in St. Thomas' cardioplegic solution, with taurine (10 mM; taurine group, n = 8) or without taurine (control group, n = 8), for 6 h at 4 degrees C. After storage, the hearts were reperfused and heart rate (HR), coronary flow (CF), left ventricular developed pressure (LVP), and positive maximum left ventricular developing pressure (max LV dp/dt) were measured. The LV tissue was examined immunohistochemically for determining DNA oxidative stress and cell apoptosis. Compared with control groups, recovery of LVP (P < 0.001), max LV dp/dt (P < 0.001), and coronary flow (P < 0.001) were significantly enhanced, whereas glutamic oxaloacetic transaminase (P < 0.01), lactate dehydrogenase (P < 0.05), creatine phosphate kinase (P < 0.01), 8-hydroxy-2'-deoxyguanosine index (P < 0.01), caspase-3 mRNA expression (P < 0.05), and percentage of TUNEL-positive cardiomyocytes (P < 0.05) were reduced in the taurine group. Addition of taurine to St. Thomas' cardioplegic solution improved cardiac function recovery for prolonged hypothermic rat heart preservation by suppressing DNA oxidative stress and cell apoptosis.
PMID: 16314910 [PubMed - in process]
J Pharm Pharmacol: 2005 Oct;57(10):1313-7.
Protective effect of taurine on myocardial antioxidant status in isoprenaline-induced myocardial infarction in rats.Shiny KS, Kumar SH, Farvin KH, Anandan R, Devadasan K.
Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO) Cochin-682029, India.
We have examined the protective effect of taurine on the myocardial antioxidant defense system in isoprenaline (isoproterenol)-induced myocardial infarction in rats, an animal model of myocardial infarction in man. Levels of diagnostic marker enzymes in plasma, lipid peroxides and reduced glutathione, and the activity of glutathione-dependent antioxidant enzymes and anti-peroxidative enzymes in the heart tissue were determined. Intraperitoneal administration of taurine significantly prevented the isoprenaline-induced increases in the levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase in the plasma of rats. Taurine exerted an antioxidant effect against isoprenaline-induced myocardial infarction by preventing the accumulation of lipid peroxides and by maintaining the level of reduced glutathione and the activity of glutathione peroxidase, glutathione-S-transferase, catalase and superoxide dismutase at near normality. The results indicated that the cardioprotective potential of taurine was probably due to the increase of the activity of the free radical enzymes, or to a counteraction of free radicals by its antioxidant nature, or to a strengthening of myocardial membrane by its membrane stabilizing property.
PMID: 16259760 [PubMed - indexed for MEDLINE]
