[dennie]

Dit kwam ik tegen op een forum van onze buren.

Injection Site - Steroid and Testosterone information

Vol. 281, Issue 1, 93-102, 1997


Pharmacokinetics and Pharmacodynamics of Nandrolone Esters in Oil Vehicle: Effects of Ester, Injection Site and Injection Volume
Charles F. Minto, Christopher Howe, Susan Wishart, Ann J. Conway and David J. Handelsman

Department of Anaesthesia and Pain Management, Royal North Shore Hospital (C.F.M.), and Andrology Unit, Royal Prince Alfred Hospital, Department of Medicine (C.H., S.W., A.J.C., D.J.H.), University of Sydney, Sydney, Australia



We studied healthy men who underwent blood sampling for plasma nandrolone, testosterone and inhibin measurements before and for 32 days after a single i.m. injection of 100 mg of nandrolone ester in arachis oil. Twenty-three men were randomized into groups receiving nandrolone phenylpropionate (group 1, n = 7) or nandrolone decanoate (group 2, n = 6) injected into the gluteal muscle in 4 ml of arachis oil vehicle or nandrolone decanoate in 1 ml of arachis oil vehicle injected into either the gluteal (group 3, n = 5) or deltoid (group 4, n = 5) muscles. Plasma nandrolone, testosterone and inhibin concentrations were analyzed by a mixed-effects indirect response model. Plasma nandrolone concentrations were influenced (P < .001) by different esters and injection sites, with higher and earlier peaks with the phenylpropionate ester, compared with the decanoate ester. After nandrolone decanoate injection, the highest bioavailability and peak nandrolone levels were observed with the 1-ml gluteal injection. Plasma testosterone concentrations were also influenced (P < .001) by the ester and injection site, with the most rapid, but briefest, suppression being due to the phenylpropionate ester, whereas the most sustained suppression was achieved with the 1-ml gluteal injection. Plasma inhibin concentrations were also significantly influenced by injection volume and site, with the lowest nadir occurring after the nandrolone decanoate 1-ml gluteal injection. Thus, the bioavailability and physiological effects of a nandrolone ester in an oil vehicle are greatest when the ester is injected in a small (1 ml vs. 4 ml) volume and into the gluteal vs. deltoid muscle. We conclude that the side-chain ester and the injection site and volume influence the pharmacokinetics and pharmacodynamics of nandrolone esters in an oil vehicle in men.

[Big-T]

Logisch dat een zelfde hoeveelheid (100mg) AAS makkelijker opgenomen wordt vanuit een kleine hoeveelheid olie dan een grote.

Als van de 4ML groep er 1 ML opgenomen is dan is er maar 25mg nandrolone in het bloed, als er echter 1ML opgenomen is van de 1ML groep dan is er 100mg in het bloed. Wat een interessant onderzoek, dat hadden we zelf ook wel kunnen uitvissen

PS: dat de injectieplaats bij voorkeur de billen is, is natuurlijk ook bekend. Hoe dikker de spier, hoe beter.

Maar bevestiging kan natuurlijk nooit kwaad...