Ghrp-6

[DOC.FEELGOOD]

Iemand al deze GHRP-6 gebruikt,heb zelf 10 vials staan

graag wat meer info hoe te gebruiken


heb ze gewoon xstra mee besteld ,

kijken of het wat is


greetz
by Anthony Roberts - GHRP-6 is a peptide in the growth factor family. It has strong effect on the release of Growth Hormone (GH). Its main use is to promote food intake by stimulating hunger and aid in energy metabolism. It can be used in the treatment of GH deficiency as well as cachexia, eating disorders and obesity.

Background

Although still relatively new, peptides have recently become popular as performance enhancing drugs. GHRP-6 is currently available from a few research companies.

Action

The major side effect accompanied by the use of GHRP-6 is a significant increase in appetite due to a stimulating the release of Ghrelin, a peptide which is released naturally in the lining of the stomach and increases hunger and gastric emptying.

GHRP-6 causes stimulation of the anterior pituitary gland which ultimately causes an increase in GH release. Since GHRP-6 acts directly on the feedback loop which signals the inhibition of GH release, when natural GH secretion has been inhibited by long term synthetic use, GHRP-6 can be used to re-stimulate the natural production of GH. GHRP-6 also affects the central nervous system, by protecting neurons as well as increasing strength in a way very similar to the way certain steroids in the Dihydrotestosterone family do.

Benefits of increased Growth Hormone levels through GHRP-6 stimulation include: an increase in strength, muscle mass and body fat loss, rejuvenation and strengthening of joints, connective tissue and bone mass. Enhanced GH secretion also leads to the liver secreting more IGF-1 (Insulin-Like Growth Factor 1), which is thought to be the primary anabolic mechanism of action for Growth Hormone.



Technical Data

It has also been discovered that when GHRP-6 and insulin are used simultaneously, GH response to GHRP-6 is increased (1). A recent study in normal mice showed significant differences in body composition, muscle growth, glucose metabolism, memory and cardiac function in the mice being administered the GHRP-6 (2). There are still many questions regarding this fairly new compound, scientists are hoping with to gain a better clinical understanding of the peptide through further research over the next few years.

User Notes

I used this stuff at a dose of 500-600 mcg/day for awhile and found that the weight gain (mostly from an increase in my appetite) was far too great. I gained a ton of weight (on par with the most potent anabolics) but it wasn’t pretty.

The effects on my joints were very beneficial at that dose also, but I didn’t really find much of a drop off when I lowered the dose to 100-200 mcg/day. In fact, I have a sprinter friend who ran a personal best with a combination of low dose GHRP-6 (100-150 mcg/day or so) and Anavar (20 mgs); that wouldn’t be a huge deal but for the fact that this was done while rehabilitating an injury!

On the other hand, even that low dose was too much for a figure competitor I know, who gained far too much weight from using GHRP-6 and ultimately had to discontinue using it after only a couple weeks.

Although this stuff can have GH-like effects, the weight increase makes any possible fat burning effects almost unnoticeable. For a bulking cycle, and at the price, it’s almost a must-have, if you’re looking to gain a ton of weight or trying to rehab an injury.

Substance name SK&F 110679; Growth Hormone Releasing Hexapeptide (GHRP-6)
Chemical name (sequence) histidyl-tryptophyl-alanyl-tryptophyl-phenylalanyl-lysinamide; {HIS}{d-TRP}{ALA}{TRP}{d-PHE}{LYS}-NH2
Systematic name (2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(3H-imidazol-4-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenyl-propanoyl]amino]hexanamide
Index name L-Lysinamide, L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-
CAS Number 87616-84-0
Merck Index Number N/A
Molecular formula C46-H56-N12-O6
Molecular weight 873.026
Legal Status ??
Route of Administration Subcutaneous injection, Intramuscular Injection

References

[Navy]

Denk dat CJC-1295 interessanter is.
Minder injecties. lagere dosis. minder koste.

[Navy]

CJC-1295
(written by LakeMountD)

GHRH1-44, also known as Growth Hormone Releasing Hormone (other synonyms are GRF and GHRF), is a peptide that is produced in the hypothalamus and secreted to stimulate the release of human growth hormone (hGH). It consists of a 44 amino acid long sequence and is released in a pulsatile fashion similar to the pulsatile release of hGH. The active portion of this peptide can be found as a 29 amino acid long peptide and is appropriately named GHRH1-29. This pulsatile release of various peptides is due to the negative feedback loop that is part of the hGH axis and controls the amount of hGH that your body produces to keep it in a homeostatic environment. Despite the effectiveness of GHRH to stimulate growth hormone release there are a number of problems associated with using it in vivo. The most noteworthy problem is the half life of the peptide, which has been shown to be ~7 minutes using advanced HPLC technologies that have proven to be very accurate. The reason for this relatively short half life is due to an enzyme called dipeptidylaminopeptidase IV (DPP-IV), which has a high affinity for the amino acids Ala and Pro and in the case of GHRH it cleaves the 1 and 2 positions that consist of Tyr-Ala, creating GHRH3-29, an inactive form of the peptide. To prevent the problems associated with natural GHRH, pharmaceutical companies looked at new ways to increase the half life and bioavailability of these smaller peptides with technologies that work far different than other technologies, such as PEGylation.

This brings us to the introduction of a far more stable form of GHRH called CJC-1295. CJC-1295 is a tetrasubstituted peptide analogue of GHRH with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. These substitutions are key in increasing the overall half life of CJC-1295 but there lies an even greater reason as to why the half life has been extended from ~7 minutes to greater than 7 days! Bioconjugation is a relatively newer technology that takes a reactive group and attaches it to a peptide, which in turn reacts with a nucleophilic (usually a partially negative molecule) entity found in the blood to form a more stable bond. Albumin, one of the most abundant substances in the human body is chosen as the nucelophile by this particular peptide thanks to a Cys34 thiol group that attracts it. By combining the tetrasubstituted GHRH analogue with maleimodoproprionic acid using a Lys linker, you create a GHRH peptide with a high binding affinity for albumin. Once the CJC-1295 molecule has attached itself to albumin, it is given an extended half life and bioavailability thanks to the albumin preventing enzymatic degredation and kidney excretion. In fact, bioconjugation is so effective that there was less than 1% of CJC-1295 left unreacted in vivo and over 90% was stabilized after subcutaneous injection. This means that you get more of what you paid for working for you. There was no DPP-IV degredation observed on CJC-1295 in any of the various experiments conducted.

Due to the extremely long half life of CJC-1295 it is plausible to use this peptide once per week with outstanding results. Much like compounds such as testosteron enanthate, however, it would be wiser to use ½ dosages twice per week to keep serum levels high and to get maximal GH release and limit the pulsatile fashion of hGH. Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection! Not only that but they proved the mean half life to be 5.8-8.1 days and after multiple doses showed mean IGF-1 levels remained above baseline for up to 28 days following! No serious adverse reactions were reported in any group. The graphs below show that this peptide has the ability to stimulate growth hormone very significantly and is much more cost effective than illegally buying hGH.

Another very positive benefit of CJC-1295 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS is decreased significantly in older adults and also with people who tend to exercise later in the evening. This peptide has a benefit to side effect ratio that exceeds all others currently being legally sold and would make a great addition to ones training regimen or post cycle therapy.

[Navy]

Maar goed. je hebt het spul al staan. dat maakt mijn reactie nutteloos.
Zelf begin ik over een week of 3-4 met CJC-1295, voor een week of 14.
Waarschijnlijk langer als het goed bevalt.

2 x per week 500mcg (of 1000mcg in 1 x ben zelf nog veel aan het uitzoeken)
Vials komen meestal met 2mg/ml (1ml) wat dus genoeg is voor 2wkn. koste: rond de 75 dollar per 2mg. Prijs zeer gunstig dus.

[koen85]

In hoeverre werkt het spul eigenlijk navy? Kun je daar een cijfer op trekken?

[jacky den bels]

staat toch eigenlijk in dat stuk dat je het beste twee keer per week kunt zetten maar als je dat gaat gebruiken Navy loggen...