Effect groeihormoon op groeifactoren

[Cools]

http://en.wikipedia.org/wiki/Growth_factor

Effect of recombinant human GH on circulating granulocyte colony-stimulating factor and neutrophils in patients with adult GH deficiency
http://www.eje-online.org/cgi/content/abstract/152/2/211

Granulocyte colony-stimulating factor (G-CSF) is een zeer intressante groeifactor. Deze stimuleert de vrijlating van stamcellen uit het beenmerg in het bloed. Deze wordt gebruikt voor stamceldonati, maar stimuleert ook de omzetting van deze naar neutrofielen.

 

[mack10]

Vertaling? Het is zondag man.

 

[Gouwetonny]

Ja en dus....

 

[Cools]

Ja,onderzoekers hebben hun altijd afgevraagd of gh het lichaam kan herstellen en verjongen.En uit deze gegevens kan je afleiden dat het zo is.
Er is ook altijd gezegd dat gh geen effect heeft op herstel en groei hersenen en weer kan je uit dit afleiden dat het zo wel is.

 

[Gouwetonny]

Ja,onderzoekers hebben hun altijd afgevraagd of gh het lichaam kan herstellen en verjongen.En uit deze gegevens kan je afleiden dat het zo is.
Er is ook altijd gezegd dat gh geen effect heeft op herstel en groei hersenen en weer kan je uit dit afleiden dat het zo wel is.

Wauw en dat ondek jij zo even. Domme wetenschappers hebben vast ook geen wiki h'e.

 

[Cools]

Wauw en dat ondek jij zo even. Domme wetenschappers hebben vast ook geen wiki h'e.

tja,wist jij het? Staat niet in de wiki.

 

[tranquilo]

wat is wiki?

 

[kix]

Ja en dus....

Wauw en dat ondek jij zo even. Domme wetenschappers hebben vast ook geen wiki h'e.

Cools voorziet ons in ieder geval van informatie, of het nu oud of nieuw is dat doet er even niet toe. Wat heb jij dan toe te voegen met je lame comments?

 

[mack10]

Waarom bumpen?

 

[Cools]

Ja, en niet een al te beste bump Toch bedankt. Was pas in het begin van men onderzoek naar groeifactoren. Kan hem wel eens mooi gaan aanvullen nu.

Dus GH kan door bepaalde groeifactoren te stimuleren het herstel in het lichaam bevorderen, maar het verouderingsproces wordt dus ook bevorderd. Door IGF-1 stimulatie verhoog je de kans op kankers ook weer en versnelde groei. Welke groeifactoren allemaal gestimuleerd worden door GH en de effecten op het lichaam is wel interessant om eens neer te zetten.

'Un-growth hormone' increases longevity
http://www.physorg.com/news/2010-12-un-growth-hormone-longevity.html

Hier kan je zien dat groeihormoon verminderen het leven kan verlengen.

 

[daniel20]

Ondertussen al wat wijzer geworden? hormonen gebruikt?

 

[Cools]

Ikzelf heb vooral G-CSF (granulocyte colony stimulating factor) gebruikt. Heb ze totale witte bloedcellen tot 20000 gekregen (wat teveel is) door aanbevolen dosis te gebruiken. Met vooral neutrofielen aanwezig (70%). Nu kan ik ze stabiel op 10000 houden met zelfde % neutrofielen.

Dit komt omdat G-CSF de stamcellen die vrijkomen aanzet tot het aanmaken van neutrofielen. Een beter middel zou GM-CSF (granulocyte macrophage stimulating factor) zijn. Deze zet aan tot de aanmaak van alle witte bloedcellen. Is alleen iets moeilijker aan te geraken en iets duurder.

De andere groeifactoren heb ik ook allemaal bestudeerd en elk hebben hun interessante eigenschappen, die gebruikt kunnen worden voor herstel van het lichaam (met elk hun eigen mogelijke bijwerkingen). Een van de interessante dingen is dat het combineren van G-CSF met Mozobil (een synthetisch middel dat werkt zoals G-CSF en GM-CSF) en VEGF (vascular endothelial growth factor) stamcellen vrijlaat die het lichaam kunnen herstellen.

http://www.newscientist.com/article/dn16383-drugs-unlock-the-bodys-own-stem-cell-cabinet.html

However, the real breakthrough of the work at Imperial was to show that by giving a different combination - Mozobil preceded by vascular endothelial growth factor (VEGF) - they could boost levels of two other types of stem cell.

Mesenchymal stem cells (MSCs) promote regeneration of bone and tissue, and so could be used for bone repair. They also damp down inflammation, and could be used to treat conditions such as rheumatoid arthritis.

Epithelial progenitor cells (EPCs), meanwhile, stimulate the growth and repair of blood vessels, and could prove useful in restoring blood flow to the heart or brain following heart attacks or strokes.



Hematopoietic stem cells convert into liver cells within days without fusion
http://www.nature.com/ncb/journal/v6/n6/abs/ncb1132.html

Human hematopoietic stem/progenitor-enriched CD34+ cells are mobilized into peripheral blood during stress related to ischemic stroke or acute myocardial infarction
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0609.2005.00536.x/full

Enhanced Stem Cells Promote Tissue Regeneration
http://www.sciencedaily.com/releases/2009/10/091005161120.htm

 

[Cools]

Vascular endothelial growth factor
http://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor

Vascular endothelial growth factor (VEGF) and its receptors
http://www.fasebj.org/content/13/1/9.full

New Role of Vascular Endothelial Growth Factor in Regulating Skin Cancer Stem Cells
http://www.sciencedaily.com/releases/2011/10/111020094335.htm

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
http://www.ncbi.nlm.nih.gov/pubmed/9804796

Radiation-enhanced vascular endothelial growth factor (VEGF) secretion in glioblastoma multiforme cell lines--a clue to radioresistance?
http://www.ncbi.nlm.nih.gov/pubmed/16193379





Epidermal growth factor
http://en.wikipedia.org/wiki/Epidermal_growth_factor

Epidermal growth factor enhances TNF-alpha-induced priming of human neutrophils.
Immunology letters 2005;96(2):203-10.
[Link niet meer beschikbaar]

Effects of epidermal growth factor on bone formation and resorption in vivo
http://ajpendo.physiology.org/content/258/2/E275.abstract

Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity
http://www.biomedcentral.com/1752-0509/5/29

EPIDERMAL GROWTH FACTOR RECEPTOR EXPRESSION IN THE LIVER OF CIRRHOTIC PATIENTS
[Link niet meer beschikbaar]

Epidermal growth factor down-regulates the expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells
http://onlinelibrary.wiley.com/doi/10.1002/cncr.25803/abstract

Epidermal Growth Factor Protects the Liver Against Alcohol-Induced Injury and Sensitization to Bacterial Lipopolysaccharide
http://onlinelibrary.wiley.com/doi/10.1111/j.1530-0277.2002.tb02616.x/abstract




Hepatocyte growth factor
http://en.wikipedia.org/wiki/Hepatocyte_growth_factor

Signaling of Hepatocyte Growth Factor Receptor
[Link niet meer beschikbaar]

HGF hepatocyte growth factor (hepapoietin A; scatter factor) [ Homo sapiens ]
http://www.ncbi.nlm.nih.gov/gene/3082

Hepatocyte growth factor signaling pathway inhibits cholesterol 7α-hydroxylase and bile acid synthesis in human hepatocytes
http://onlinelibrary.wiley.com/doi/10.1002/hep.21878/full

Loss of Hepatocyte Growth Factor/c-Met Signaling Pathway Accelerates Early Stages of N-nitrosodiethylamine–Induced Hepatocarcinogenesis
http://cancerres.aacrjournals.org/content/67/20/9844

Radiation-enhanced hepatocyte growth factor secretion in malignant glioma cell lines.
http://www.ncbi.nlm.nih.gov/pubmed/17765959






Transforming growth factor
http://en.wikipedia.org/wiki/Transforming_growth_factor

Het effect van Transforming Growth Factor-beta1 op oligodendrocyten
http://doclib.uhasselt.be/dspace/handle/1942/1150

Transforming growth factor beta 1 increases IgA isotype switching at the clonal level
http://www.jimmunol.org/content/145/11/3773.abstract

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
http://www.pnas.org/content/83/12/4167.short

Transforming growth factor-beta in disease: the dark side of tissue repair.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC443055/

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production
http://www.pnas.org/content/84/16/5788.short





Insulin-like growth factor 1
http://en.wikipedia.org/wiki/Insulin-like_growth_factor_1

Insulin-like growth factor
http://en.wikipedia.org/wiki/Insulin-like_growth_factor

Effects of Growth Hormone and Insulin-Like Growth Factor-I on Radiation Enteritis
http://content.karger.com/ProdukteDB/produkte.asp?Doi=8592

Cardiovascular Effects of Insulin-Like Growth Factor-1 and Growth Hormone in Chronic Left Ventricular Failure in the Rat
[Link niet meer beschikbaar]

Neuroprotective effects of insulin-like growth factor-I (IGF-I) following a penetrating brain injury in rats
http://www.sciencedirect.com/science...0689930303525X

Neuroprotective effect of insulin-like growth factor I in immortalized hypothalamic cells.
[Link niet meer beschikbaar]

Insulin-Like Growth Factor 1 and Prostate Cancer Risk: A Population-Based, CaseControl Study
http://jnci.oxfordjournals.org/content/90/12/911.short

Plasma androgens, IGF-1, body size, and prostate cancer risk: a synthetic review
http://www.ncbi.nlm.nih.gov/sites/en...,f1000m,isrctn





Growth hormone
http://en.wikipedia.org/wiki/Growth_hormone

Effects of Growth Hormone Therapy on Thyroid Function of Growth Hormone-Deficient Adults with and without Concomitant Thyroxine-Substituted Central Hypothyroidism*
http://jcem.endojournals.org/content/69/6/1127.abstract

Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC508055/

Growth Hormone Induces Low-Density Lipoprotein Clearance but not Bile Acid Synthesis in Humans
http://atvb.ahajournals.org/content/24/2/349.abstract

Growth Hormone Replacement Therapy Induces Insulin Resistance by Activating the Glucose-Fatty Acid Cycle
http://jcem.endojournals.org/content/88/4/1455.full

Growth hormone-secretory patterns in androgen-resistant (testicular feminized) rats.
http://www.ncbi.nlm.nih.gov/pubmed/3780546

Developmental Action of Estrogen Receptor-α Feminizes the Growth Hormone-Stat5b Pathway and Expression of Cyp2a4 andCyp2d9 Genes in Mouse Liver
http://molpharm.aspetjournals.org/content/56/3/473.full





Granulocyte macrophage colony-stimulating factor
http://en.wikipedia.org/wiki/Granulocyte_macrophage_colony-stimulating_factor

Effect of GM-CSF on cytokine induction by soluble beta-glucan SCG in vitro in beta-glucan-treated mice.
http://www.ncbi.nlm.nih.gov/pubmed/19563398

GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism
http://www.nature.com/nature/journal/v332/n6165/abs/332647a0.html





Granulocyte colony-stimulating factor
http://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor

Cardiovascular cell therapy and endogenous repair
http://onlinelibrary.wiley.com/doi/10.1111/j.1463-1326.2008.00937.x/full

The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1172228/

G-CSF administration in a small-for-size liver model.
http://www.ncbi.nlm.nih.gov/pubmed/19466653

G-CSF and GM-CSF for treating or preventing neonatal infections
http://www.nichd.nih.gov/cochrane/carr/carr.htm

G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases
http://bloodjournal.hematologylibrary.org/content/102/2/734.short

G-CSF in Peg-IFN induced neutropenia in liver transplanted patients with HCV recurrence
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778101/

G-CSF Neupogen cured a terminal liver cancer
http://www.drugs.com/forum/latest-d...upogen-cured-terminal-liver-cancer-28514.html

G-CSF protects dopaminergic neurons from 6-OHDA-induced toxicity via the ERK pathway.
http://www.mendeley.com/research/gc...eurons-6ohdainduced-toxicity-via-erk-pathway/

G-CSF reduces IFN- and IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function
http://www.nature.com/bmt/journal/v25/n10/abs/1702402a.html

G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice
http://www.nature.com/jcbfm/journal/v25/n4/full/9600033a.html

Granulocyte colony-stimulating factor (G-CSF) production and G-CSF receptor structure in patients with congenital neutropenia.
http://www.ncbi.nlm.nih.gov/pubmed/7510142

Granulocyte colony-stimulating factor "mobilized" peripheral blood progenitor cells accelerate granulocyte and platelet recovery after high-dose chemotherapy
http://bloodjournal.hematologylibrary.org/content/81/8/2031.short

Enhancement of oxidative response and damage caused by human neutrophils to Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon
http://iai.asm.org/content/61/4/1185.abstract

The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1
http://bloodjournal.hematologylibrary.org/content/115/19/3970.full

Ultrafiltered pig leukocyte extract (UPLE, IMUNOR) potentiates hematopoiesis-stimulating effects of G-CSF in vitro and improves the outcome of treatment of hematopoietic radiation damage in mice with G-CSF.
http://www.ncbi.nlm.nih.gov/pubmed/16435582

G-CSF enhanced granulocyte production in a child with severe neutropenia in the setting of fatal virus-associated hemophagocytic syndrome
http://onlinelibrary.wiley.com/doi/10.1002/ajh.2830350409/abstract

G-CSF-induced spleen size changes in peripheral blood progenitor cell donors
http://onlinelibrary.wiley.com/doi/10.1046/j.1537-2995.2003.00384.x/abstract

G-CSF enhances the immunoglobulin generation rather than the proliferation of human B lymphocytes
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0609.1993.tb00615.x/abstract

Elevated liver function tests (LFTs) associated with filgrastim (G-CSF) priming and leukapheresis of peripheral blood progenitor cells (Meeting abstract).
http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=29&abstractID=8911

Long term G-CSF-induced remission of ulcerative colitis-like inflammatory bowel disease in a patient with glycogen storage disease Ib and evaluation of associated neutrophil function.
http://www.bioportfolio.com/resourc...cerative-Colitis-like-Inflammatory-Bowel.html

G-CSF–primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair programs
http://www.exphem.org/article/S0301-472X(04)00319-4/abstract

Feasibility and safety of G-CSF administration to induce bone marrow-derived cells mobilization in patients with end stage liver disease☆
http://www.jhep-elsevier.com/article/S0168-8278(06)00175-9/abstract

Mature polymorphonuclear leukocytes express high-affinity receptors for IgG (Fc gamma RI) after stimulation with granulocyte colony-stimulating factor (G-CSF)
http://www.jleukbio.org/content/57/3/455.short

Effects of granulocyte colony-stimulating factor and interferon-gamma on antifungal activity of human polymorphonuclear neutrophils against pseudohyphae of different medically important Candida species
http://www.jleukbio.org/content/57/4/651.abstract

 

[Cools]

Morgen komt er nog een deel bij, orden ik alles en komt er uitleg over bepaalde dingen. Pdf's komen er ook. Dit is al heel wat leesmateriaal voor de geïnteresseerden.

 

[mack10]

Nice Cools!

 

[daniel20]

goed bezig inderdaad, thanks voor de informatie.

 

[The Back]

Mooi man , blijf deze topic maar mooi aanvullen.
Enkel spijtig dat er zoveel op muizen en ratten wordt getest en zoweinig op mensen

thx

 

[Cools]

Haha, ja idd. Had liever ook meer op mensen gezien. Maar we moeten t er voorlopig mee doen. Ga ze strax wel ordenen, mensen, muizen en in vitro. En nog andere interessante groeifactoren toevoegen.

 

[mack10]

Ik bied me aan

 

[Cools]

AMD3100 is het middel mozobil (plerixafor) http://en.wikipedia.org/wiki/Plerixafor